Exclusion of small terminase mediated DNA threading models for genome packaging in bacteriophage T4
Identifieur interne : 001264 ( Main/Exploration ); précédent : 001263; suivant : 001265Exclusion of small terminase mediated DNA threading models for genome packaging in bacteriophage T4
Auteurs : Song Gao [États-Unis, République populaire de Chine] ; Liang Zhang [États-Unis] ; Venigalla B. Rao [États-Unis]Source :
- Nucleic Acids Research [ 0305-1048 ] ; 2016.
Descripteurs français
- KwdFr :
- ADN viral (), ADN viral (physiologie), Assemblage viral, Bactériophage T4 (physiologie), Endodeoxyribonucleases (), Endodeoxyribonucleases (physiologie), Escherichia coli (virologie), Génome viral, Liaison aux protéines, Modèles moléculaires, Protéines de liaison à l'ADN (), Protéines de liaison à l'ADN (physiologie), Protéines virales (), Protéines virales (physiologie), Structure en hélice alpha, Structure tertiaire des protéines.
- MESH :
- physiologie : ADN viral, Bactériophage T4, Endodeoxyribonucleases, Protéines de liaison à l'ADN, Protéines virales.
- virologie : Escherichia coli.
- ADN viral, Assemblage viral, Endodeoxyribonucleases, Génome viral, Liaison aux protéines, Modèles moléculaires, Protéines de liaison à l'ADN, Protéines virales, Structure en hélice alpha, Structure tertiaire des protéines.
English descriptors
- KwdEn :
- Bacteriophage T4 (physiology), DNA, Viral (chemistry), DNA, Viral (physiology), DNA-Binding Proteins (chemistry), DNA-Binding Proteins (physiology), Endodeoxyribonucleases (chemistry), Endodeoxyribonucleases (physiology), Escherichia coli (virology), Genome, Viral, Models, Molecular, Protein Binding, Protein Conformation, alpha-Helical, Protein Structure, Tertiary, Viral Proteins (chemistry), Viral Proteins (physiology), Virus Assembly.
- MESH :
- chemical , chemistry : DNA, Viral, DNA-Binding Proteins, Endodeoxyribonucleases, Viral Proteins.
- physiology : Bacteriophage T4, DNA, Viral, DNA-Binding Proteins, Endodeoxyribonucleases, Viral Proteins.
- virology : Escherichia coli.
- Genome, Viral, Models, Molecular, Protein Binding, Protein Conformation, alpha-Helical, Protein Structure, Tertiary, Virus Assembly.
Abstract
Tailed bacteriophages and herpes viruses use powerful molecular machines to package their genomes. The packaging machine consists of three components: portal, motor (large terminase; TerL) and regulator (small terminase; TerS). Portal, a dodecamer, and motor, a pentamer, form two concentric rings at the special five-fold vertex of the icosahedral capsid. Powered by ATPase, the motor ratchets DNA into the capsid through the portal channel. TerS is essential for packaging, particularly for genome recognition, but its mechanism is unknown and controversial. Structures of gear-shaped TerS rings inspired models that invoke DNA threading through the central channel. Here, we report that mutations of basic residues that line phage T4 TerS (gp16) channel do not disrupt DNA binding. Even deletion of the entire channel helix retained DNA binding and produced progeny phage
Url:
DOI: 10.1093/nar/gkw184
PubMed: 26984529
PubMed Central: 4872099
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000103
- to stream Pmc, to step Curation: 000103
- to stream Pmc, to step Checkpoint: 000B72
- to stream PubMed, to step Corpus: 001205
- to stream PubMed, to step Curation: 001205
- to stream PubMed, to step Checkpoint: 001112
- to stream Ncbi, to step Merge: 001536
- to stream Ncbi, to step Curation: 001536
- to stream Ncbi, to step Checkpoint: 001536
- to stream Main, to step Merge: 001268
- to stream Main, to step Curation: 001264
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Exclusion of small terminase mediated DNA threading models for genome packaging in bacteriophage T4</title><author><name sortKey="Gao, Song" sort="Gao, Song" uniqKey="Gao S" first="Song" last="Gao">Song Gao</name><affiliation wicri:level="2"><nlm:aff id="AFF1">Department of Biology, The Catholic University of America, 620 Michigan Avenue Northeast, Washington, DC 20064, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, The Catholic University of America, 620 Michigan Avenue Northeast, Washington, DC 20064</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF2">Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Huaihai Institute of Technology, Lianyungang 222005, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Huaihai Institute of Technology, Lianyungang 222005</wicri:regionArea><wicri:noRegion>Lianyungang 222005</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Liang" sort="Zhang, Liang" uniqKey="Zhang L" first="Liang" last="Zhang">Liang Zhang</name><affiliation wicri:level="2"><nlm:aff id="AFF1">Department of Biology, The Catholic University of America, 620 Michigan Avenue Northeast, Washington, DC 20064, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, The Catholic University of America, 620 Michigan Avenue Northeast, Washington, DC 20064</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Rao, Venigalla B" sort="Rao, Venigalla B" uniqKey="Rao V" first="Venigalla B." last="Rao">Venigalla B. Rao</name><affiliation wicri:level="2"><nlm:aff id="AFF1">Department of Biology, The Catholic University of America, 620 Michigan Avenue Northeast, Washington, DC 20064, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, The Catholic University of America, 620 Michigan Avenue Northeast, Washington, DC 20064</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26984529</idno><idno type="pmc">4872099</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872099</idno><idno type="RBID">PMC:4872099</idno><idno type="doi">10.1093/nar/gkw184</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000103</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000103</idno><idno type="wicri:Area/Pmc/Curation">000103</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000103</idno><idno type="wicri:Area/Pmc/Checkpoint">000B72</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B72</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:26984529</idno><idno type="wicri:Area/PubMed/Corpus">001205</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001205</idno><idno type="wicri:Area/PubMed/Curation">001205</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001205</idno><idno type="wicri:Area/PubMed/Checkpoint">001112</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001112</idno><idno type="wicri:Area/Ncbi/Merge">001536</idno><idno type="wicri:Area/Ncbi/Curation">001536</idno><idno type="wicri:Area/Ncbi/Checkpoint">001536</idno><idno type="wicri:doubleKey">0305-1048:2016:Gao S:exclusion:of:small</idno><idno type="wicri:Area/Main/Merge">001268</idno><idno type="wicri:Area/Main/Curation">001264</idno><idno type="wicri:Area/Main/Exploration">001264</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Exclusion of small terminase mediated DNA threading models for genome packaging in bacteriophage T4</title><author><name sortKey="Gao, Song" sort="Gao, Song" uniqKey="Gao S" first="Song" last="Gao">Song Gao</name><affiliation wicri:level="2"><nlm:aff id="AFF1">Department of Biology, The Catholic University of America, 620 Michigan Avenue Northeast, Washington, DC 20064, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, The Catholic University of America, 620 Michigan Avenue Northeast, Washington, DC 20064</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF2">Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Huaihai Institute of Technology, Lianyungang 222005, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Huaihai Institute of Technology, Lianyungang 222005</wicri:regionArea><wicri:noRegion>Lianyungang 222005</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Liang" sort="Zhang, Liang" uniqKey="Zhang L" first="Liang" last="Zhang">Liang Zhang</name><affiliation wicri:level="2"><nlm:aff id="AFF1">Department of Biology, The Catholic University of America, 620 Michigan Avenue Northeast, Washington, DC 20064, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, The Catholic University of America, 620 Michigan Avenue Northeast, Washington, DC 20064</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Rao, Venigalla B" sort="Rao, Venigalla B" uniqKey="Rao V" first="Venigalla B." last="Rao">Venigalla B. Rao</name><affiliation wicri:level="2"><nlm:aff id="AFF1">Department of Biology, The Catholic University of America, 620 Michigan Avenue Northeast, Washington, DC 20064, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, The Catholic University of America, 620 Michigan Avenue Northeast, Washington, DC 20064</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author></analytic><series><title level="j">Nucleic Acids Research</title><idno type="ISSN">0305-1048</idno><idno type="eISSN">1362-4962</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bacteriophage T4 (physiology)</term><term>DNA, Viral (chemistry)</term><term>DNA, Viral (physiology)</term><term>DNA-Binding Proteins (chemistry)</term><term>DNA-Binding Proteins (physiology)</term><term>Endodeoxyribonucleases (chemistry)</term><term>Endodeoxyribonucleases (physiology)</term><term>Escherichia coli (virology)</term><term>Genome, Viral</term><term>Models, Molecular</term><term>Protein Binding</term><term>Protein Conformation, alpha-Helical</term><term>Protein Structure, Tertiary</term><term>Viral Proteins (chemistry)</term><term>Viral Proteins (physiology)</term><term>Virus Assembly</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral ()</term><term>ADN viral (physiologie)</term><term>Assemblage viral</term><term>Bactériophage T4 (physiologie)</term><term>Endodeoxyribonucleases ()</term><term>Endodeoxyribonucleases (physiologie)</term><term>Escherichia coli (virologie)</term><term>Génome viral</term><term>Liaison aux protéines</term><term>Modèles moléculaires</term><term>Protéines de liaison à l'ADN ()</term><term>Protéines de liaison à l'ADN (physiologie)</term><term>Protéines virales ()</term><term>Protéines virales (physiologie)</term><term>Structure en hélice alpha</term><term>Structure tertiaire des protéines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA, Viral</term><term>DNA-Binding Proteins</term><term>Endodeoxyribonucleases</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>ADN viral</term><term>Bactériophage T4</term><term>Endodeoxyribonucleases</term><term>Protéines de liaison à l'ADN</term><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bacteriophage T4</term><term>DNA, Viral</term><term>DNA-Binding Proteins</term><term>Endodeoxyribonucleases</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Escherichia coli</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Escherichia coli</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Genome, Viral</term><term>Models, Molecular</term><term>Protein Binding</term><term>Protein Conformation, alpha-Helical</term><term>Protein Structure, Tertiary</term><term>Virus Assembly</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ADN viral</term><term>Assemblage viral</term><term>Endodeoxyribonucleases</term><term>Génome viral</term><term>Liaison aux protéines</term><term>Modèles moléculaires</term><term>Protéines de liaison à l'ADN</term><term>Protéines virales</term><term>Structure en hélice alpha</term><term>Structure tertiaire des protéines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Tailed bacteriophages and herpes viruses use powerful molecular machines to package their genomes. The packaging machine consists of three components: portal, motor (large terminase; TerL) and regulator (small terminase; TerS). Portal, a dodecamer, and motor, a pentamer, form two concentric rings at the special five-fold vertex of the icosahedral capsid. Powered by ATPase, the motor ratchets DNA into the capsid through the portal channel. TerS is essential for packaging, particularly for genome recognition, but its mechanism is unknown and controversial. Structures of gear-shaped TerS rings inspired models that invoke DNA threading through the central channel. Here, we report that mutations of basic residues that line phage T4 TerS (gp16) channel do not disrupt DNA binding. Even deletion of the entire channel helix retained DNA binding and produced progeny phage <italic>in vivo</italic>. On the other hand, large oligomers of TerS (11-mers/12-mers), but not small oligomers (trimers to hexamers), bind DNA. These results suggest that TerS oligomerization creates a large outer surface, which, but not the interior of the channel, is critical for function, probably to wrap viral genome around the ring during packaging initiation. Hence, models involving TerS-mediated DNA threading may be excluded as an essential mechanism for viral genome packaging.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hendrix, R W" uniqKey="Hendrix R">R.W. Hendrix</name></author><author><name sortKey="Smith, M C" uniqKey="Smith M">M.C. Smith</name></author><author><name sortKey="Burns, R N" uniqKey="Burns R">R.N. Burns</name></author><author><name sortKey="Ford, M E" uniqKey="Ford M">M.E. Ford</name></author><author><name sortKey="Hatfull, G F" uniqKey="Hatfull G">G.F. Hatfull</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, V B" uniqKey="Rao V">V.B. Rao</name></author><author><name sortKey="Feiss, M" uniqKey="Feiss M">M. Feiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casjens, S R" uniqKey="Casjens S">S.R. Casjens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chemla, Y R" uniqKey="Chemla Y">Y.R. Chemla</name></author><author><name sortKey="Smith, D E" uniqKey="Smith D">D.E. Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oliveira, L" uniqKey="Oliveira L">L. Oliveira</name></author><author><name sortKey="Tavares, P" uniqKey="Tavares P">P. Tavares</name></author><author><name sortKey="Alonso, J C" uniqKey="Alonso J">J.C. Alonso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, V B" uniqKey="Rao V">V.B. Rao</name></author><author><name sortKey="Feiss, M" uniqKey="Feiss M">M. Feiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Black, L W" uniqKey="Black L">L.W. Black</name></author><author><name sortKey="Rao, V B" uniqKey="Rao V">V.B. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, V B" uniqKey="Rao V">V.B. Rao</name></author><author><name sortKey="Black, L W" uniqKey="Black L">L.W. Black</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghosh Kumar, M" uniqKey="Ghosh Kumar M">M. Ghosh-Kumar</name></author><author><name sortKey="Alam, T I" uniqKey="Alam T">T.I. Alam</name></author><author><name sortKey="Draper, B" uniqKey="Draper B">B. Draper</name></author><author><name sortKey="Stack, J D" uniqKey="Stack J">J.D. Stack</name></author><author><name sortKey="Rao, V B" uniqKey="Rao V">V.B. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, V B" uniqKey="Rao V">V.B. Rao</name></author><author><name sortKey="Black, L W" uniqKey="Black L">L.W. Black</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leffers, G" uniqKey="Leffers G">G. Leffers</name></author><author><name sortKey="Rao, V B" uniqKey="Rao V">V.B. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kondabagil, K R" uniqKey="Kondabagil K">K.R. Kondabagil</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Rao, V B" uniqKey="Rao V">V.B. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baumann, R G" uniqKey="Baumann R">R.G. Baumann</name></author><author><name sortKey="Black, L W" uniqKey="Black L">L.W. Black</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baumann, R G" uniqKey="Baumann R">R.G. Baumann</name></author><author><name sortKey="Mullaney, J" uniqKey="Mullaney J">J. Mullaney</name></author><author><name sortKey="Black, L W" uniqKey="Black L">L.W. Black</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, L" uniqKey="Sun L">L. Sun</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Gao, S" uniqKey="Gao S">S. Gao</name></author><author><name sortKey="Rao, P A" uniqKey="Rao P">P.A. Rao</name></author><author><name sortKey="Padilla Sanchez, V" uniqKey="Padilla Sanchez V">V. Padilla-Sanchez</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S. Sun</name></author><author><name sortKey="Xiang, Y" uniqKey="Xiang Y">Y. Xiang</name></author><author><name sortKey="Subramaniam, S" uniqKey="Subramaniam S">S. Subramaniam</name></author><author><name sortKey="Rao, V B" uniqKey="Rao V">V.B. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fuller, D N" uniqKey="Fuller D">D.N. Fuller</name></author><author><name sortKey="Raymer, D M" uniqKey="Raymer D">D.M. Raymer</name></author><author><name sortKey="Kottadiel, V I" uniqKey="Kottadiel V">V.I. Kottadiel</name></author><author><name sortKey="Rao, V B" uniqKey="Rao V">V.B. Rao</name></author><author><name sortKey="Smith, D E" uniqKey="Smith D">D.E. Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simpson, A A" uniqKey="Simpson A">A.A. Simpson</name></author><author><name sortKey="Tao, Y" uniqKey="Tao Y">Y. Tao</name></author><author><name sortKey="Leiman, P G" uniqKey="Leiman P">P.G. Leiman</name></author><author><name sortKey="Badasso, M O" uniqKey="Badasso M">M.O. Badasso</name></author><author><name sortKey="He, Y" uniqKey="He Y">Y. He</name></author><author><name sortKey="Jardine, P J" uniqKey="Jardine P">P.J. Jardine</name></author><author><name sortKey="Olson, N H" uniqKey="Olson N">N.H. Olson</name></author><author><name sortKey="Morais, M C" uniqKey="Morais M">M.C. Morais</name></author><author><name sortKey="Grimes, S" uniqKey="Grimes S">S. Grimes</name></author><author><name sortKey="Anderson, D L" uniqKey="Anderson D">D.L. Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lebedev, A A" uniqKey="Lebedev A">A.A. Lebedev</name></author><author><name sortKey="Krause, M H" uniqKey="Krause M">M.H. Krause</name></author><author><name sortKey="Isidro, A L" uniqKey="Isidro A">A.L. Isidro</name></author><author><name sortKey="Vagin, A A" uniqKey="Vagin A">A.A. Vagin</name></author><author><name sortKey="Orlova, E V" uniqKey="Orlova E">E.V. Orlova</name></author><author><name sortKey="Turner, J" uniqKey="Turner J">J. Turner</name></author><author><name sortKey="Dodson, E J" uniqKey="Dodson E">E.J. Dodson</name></author><author><name sortKey="Tavares, P" uniqKey="Tavares P">P. Tavares</name></author><author><name sortKey="Antson, A A" uniqKey="Antson A">A.A. Antson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Padilla Sanchez, V" uniqKey="Padilla Sanchez V">V. Padilla-Sanchez</name></author><author><name sortKey="Gao, S" uniqKey="Gao S">S. Gao</name></author><author><name sortKey="Kim, H R" uniqKey="Kim H">H.R. Kim</name></author><author><name sortKey="Kihara, D" uniqKey="Kihara D">D. Kihara</name></author><author><name sortKey="Sun, L" uniqKey="Sun L">L. Sun</name></author><author><name sortKey="Rossmann, M G" uniqKey="Rossmann M">M.G. Rossmann</name></author><author><name sortKey="Rao, V B" uniqKey="Rao V">V.B. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olia, A S" uniqKey="Olia A">A.S. Olia</name></author><author><name sortKey="Prevelige, P E" uniqKey="Prevelige P">P.E. Prevelige</name></author><author><name sortKey="Johnson, J E" uniqKey="Johnson J">J.E. Johnson</name></author><author><name sortKey="Cingolani, G" uniqKey="Cingolani G">G. Cingolani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, H" uniqKey="Zhao H">H. Zhao</name></author><author><name sortKey="Christensen, T E" uniqKey="Christensen T">T.E. Christensen</name></author><author><name sortKey="Kamau, Y N" uniqKey="Kamau Y">Y.N. Kamau</name></author><author><name sortKey="Tang, L" uniqKey="Tang L">L. Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, S" uniqKey="Sun S">S. Sun</name></author><author><name sortKey="Kondabagil, K" uniqKey="Kondabagil K">K. Kondabagil</name></author><author><name sortKey="Draper, B" uniqKey="Draper B">B. Draper</name></author><author><name sortKey="Alam, T I" uniqKey="Alam T">T.I. Alam</name></author><author><name sortKey="Bowman, V D" uniqKey="Bowman V">V.D. Bowman</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Hegde, S" uniqKey="Hegde S">S. Hegde</name></author><author><name sortKey="Fokine, A" uniqKey="Fokine A">A. Fokine</name></author><author><name sortKey="Rossmann, M G" uniqKey="Rossmann M">M.G. Rossmann</name></author><author><name sortKey="Rao, V B" uniqKey="Rao V">V.B. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roy, A" uniqKey="Roy A">A. Roy</name></author><author><name sortKey="Bhardwaj, A" uniqKey="Bhardwaj A">A. Bhardwaj</name></author><author><name sortKey="Datta, P" uniqKey="Datta P">P. Datta</name></author><author><name sortKey="Lander, G C" uniqKey="Lander G">G.C. Lander</name></author><author><name sortKey="Cingolani, G" uniqKey="Cingolani G">G. Cingolani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, H" uniqKey="Zhao H">H. Zhao</name></author><author><name sortKey="Finch, C J" uniqKey="Finch C">C.J. Finch</name></author><author><name sortKey="Sequeira, R D" uniqKey="Sequeira R">R.D. Sequeira</name></author><author><name sortKey="Johnson, B A" uniqKey="Johnson B">B.A. Johnson</name></author><author><name sortKey="Johnson, J E" uniqKey="Johnson J">J.E. Johnson</name></author><author><name sortKey="Casjens, S R" uniqKey="Casjens S">S.R. Casjens</name></author><author><name sortKey="Tang, L" uniqKey="Tang L">L. Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, S" uniqKey="Sun S">S. Sun</name></author><author><name sortKey="Gao, S" uniqKey="Gao S">S. Gao</name></author><author><name sortKey="Kondabagil, K" uniqKey="Kondabagil K">K. Kondabagil</name></author><author><name sortKey="Xiang, Y" uniqKey="Xiang Y">Y. Xiang</name></author><author><name sortKey="Rossmann, M G" uniqKey="Rossmann M">M.G. Rossmann</name></author><author><name sortKey="Rao, V B" uniqKey="Rao V">V.B. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buttner, C R" uniqKey="Buttner C">C.R. Buttner</name></author><author><name sortKey="Chechik, M" uniqKey="Chechik M">M. Chechik</name></author><author><name sortKey="Ortiz Lombardia, M" uniqKey="Ortiz Lombardia M">M. Ortiz-Lombardia</name></author><author><name sortKey="Smits, C" uniqKey="Smits C">C. Smits</name></author><author><name sortKey="Ebong, I O" uniqKey="Ebong I">I.O. Ebong</name></author><author><name sortKey="Chechik, V" uniqKey="Chechik V">V. Chechik</name></author><author><name sortKey="Jeschke, G" uniqKey="Jeschke G">G. Jeschke</name></author><author><name sortKey="Dykeman, E" uniqKey="Dykeman E">E. Dykeman</name></author><author><name sortKey="Benini, S" uniqKey="Benini S">S. Benini</name></author><author><name sortKey="Robinson, C V" uniqKey="Robinson C">C.V. Robinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nemecek, D" uniqKey="Nemecek D">D. Nemecek</name></author><author><name sortKey="Lander, G C" uniqKey="Lander G">G.C. Lander</name></author><author><name sortKey="Johnson, J E" uniqKey="Johnson J">J.E. Johnson</name></author><author><name sortKey="Casjens, S R" uniqKey="Casjens S">S.R. Casjens</name></author><author><name sortKey="Thomas, G J" uniqKey="Thomas G">G.J. Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Duijn, E" uniqKey="Van Duijn E">E. van Duijn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, H" uniqKey="Lin H">H. Lin</name></author><author><name sortKey="Simon, M N" uniqKey="Simon M">M.N. Simon</name></author><author><name sortKey="Black, L W" uniqKey="Black L">L.W. Black</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Beer, T" uniqKey="De Beer T">T. de Beer</name></author><author><name sortKey="Fang, J" uniqKey="Fang J">J. Fang</name></author><author><name sortKey="Ortega, M" uniqKey="Ortega M">M. Ortega</name></author><author><name sortKey="Yang, Q" uniqKey="Yang Q">Q. Yang</name></author><author><name sortKey="Maes, L" uniqKey="Maes L">L. Maes</name></author><author><name sortKey="Duffy, C" uniqKey="Duffy C">C. Duffy</name></author><author><name sortKey="Berton, N" uniqKey="Berton N">N. Berton</name></author><author><name sortKey="Sippy, J" uniqKey="Sippy J">J. Sippy</name></author><author><name sortKey="Overduin, M" uniqKey="Overduin M">M. Overduin</name></author><author><name sortKey="Feiss, M" uniqKey="Feiss M">M. Feiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chai, S" uniqKey="Chai S">S. Chai</name></author><author><name sortKey="Lurz, R" uniqKey="Lurz R">R. Lurz</name></author><author><name sortKey="Alonso, J C" uniqKey="Alonso J">J.C. Alonso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, H" uniqKey="Zhao H">H. Zhao</name></author><author><name sortKey="Kamau, Y N" uniqKey="Kamau Y">Y.N. Kamau</name></author><author><name sortKey="Christensen, T E" uniqKey="Christensen T">T.E. Christensen</name></author><author><name sortKey="Tang, L" uniqKey="Tang L">L. Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, S" uniqKey="Gao S">S. Gao</name></author><author><name sortKey="Rao, V B" uniqKey="Rao V">V.B. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leavitt, J C" uniqKey="Leavitt J">J.C. Leavitt</name></author><author><name sortKey="Gilcrease, E B" uniqKey="Gilcrease E">E.B. Gilcrease</name></author><author><name sortKey="Wilson, K" uniqKey="Wilson K">K. Wilson</name></author><author><name sortKey="Casjens, S R" uniqKey="Casjens S">S.R. Casjens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frackman, S" uniqKey="Frackman S">S. Frackman</name></author><author><name sortKey="Siegele, D A" uniqKey="Siegele D">D.A. Siegele</name></author><author><name sortKey="Feiss, M" uniqKey="Feiss M">M. Feiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Catalano, C E" uniqKey="Catalano C">C.E. Catalano</name></author><author><name sortKey="Cue, D" uniqKey="Cue D">D. Cue</name></author><author><name sortKey="Feiss, M" uniqKey="Feiss M">M. Feiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhardwaj, A" uniqKey="Bhardwaj A">A. Bhardwaj</name></author><author><name sortKey="Casjens, S R" uniqKey="Casjens S">S.R. Casjens</name></author><author><name sortKey="Cingolani, G" uniqKey="Cingolani G">G. Cingolani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nemecek, D" uniqKey="Nemecek D">D. Nemecek</name></author><author><name sortKey="Gilcrease, E B" uniqKey="Gilcrease E">E.B. Gilcrease</name></author><author><name sortKey="Kang, S" uniqKey="Kang S">S. Kang</name></author><author><name sortKey="Prevelige, P E" uniqKey="Prevelige P">P.E. Prevelige</name></author><author><name sortKey="Casjens, S" uniqKey="Casjens S">S. Casjens</name></author><author><name sortKey="Thomas, G J" uniqKey="Thomas G">G.J. Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kondabagil, K R" uniqKey="Kondabagil K">K.R. Kondabagil</name></author><author><name sortKey="Rao, V B" uniqKey="Rao V">V.B. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, V B" uniqKey="Rao V">V.B. Rao</name></author><author><name sortKey="Mitchell, M S" uniqKey="Mitchell M">M.S. Mitchell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horton, R M" uniqKey="Horton R">R.M. Horton</name></author><author><name sortKey="Hunt, H D" uniqKey="Hunt H">H.D. Hunt</name></author><author><name sortKey="Ho, S N" uniqKey="Ho S">S.N. Ho</name></author><author><name sortKey="Pullen, J K" uniqKey="Pullen J">J.K. Pullen</name></author><author><name sortKey="Pease, L R" uniqKey="Pease L">L.R. Pease</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biasini, M" uniqKey="Biasini M">M. Biasini</name></author><author><name sortKey="Bienert, S" uniqKey="Bienert S">S. Bienert</name></author><author><name sortKey="Waterhouse, A" uniqKey="Waterhouse A">A. Waterhouse</name></author><author><name sortKey="Arnold, K" uniqKey="Arnold K">K. Arnold</name></author><author><name sortKey="Studer, G" uniqKey="Studer G">G. Studer</name></author><author><name sortKey="Schmidt, T" uniqKey="Schmidt T">T. Schmidt</name></author><author><name sortKey="Kiefer, F" uniqKey="Kiefer F">F. Kiefer</name></author><author><name sortKey="Cassarino, T G" uniqKey="Cassarino T">T.G. Cassarino</name></author><author><name sortKey="Bertoni, M" uniqKey="Bertoni M">M. Bertoni</name></author><author><name sortKey="Bordoli, L" uniqKey="Bordoli L">L. Bordoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arnold, K" uniqKey="Arnold K">K. Arnold</name></author><author><name sortKey="Bordoli, L" uniqKey="Bordoli L">L. Bordoli</name></author><author><name sortKey="Kopp, J" uniqKey="Kopp J">J. Kopp</name></author><author><name sortKey="Schwede, T" uniqKey="Schwede T">T. Schwede</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goujon, M" uniqKey="Goujon M">M. Goujon</name></author><author><name sortKey="Mcwilliam, H" uniqKey="Mcwilliam H">H. McWilliam</name></author><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Valentin, F" uniqKey="Valentin F">F. Valentin</name></author><author><name sortKey="Squizzato, S" uniqKey="Squizzato S">S. Squizzato</name></author><author><name sortKey="Paern, J" uniqKey="Paern J">J. Paern</name></author><author><name sortKey="Lopez, R" uniqKey="Lopez R">R. Lopez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adams, P D" uniqKey="Adams P">P.D. Adams</name></author><author><name sortKey="Afonine, P V" uniqKey="Afonine P">P.V. Afonine</name></author><author><name sortKey="Bunk Czi, G" uniqKey="Bunk Czi G">G. Bunkóczi</name></author><author><name sortKey="Chen, V B" uniqKey="Chen V">V.B. Chen</name></author><author><name sortKey="Davis, I W" uniqKey="Davis I">I.W. Davis</name></author><author><name sortKey="Echols, N" uniqKey="Echols N">N. Echols</name></author><author><name sortKey="Headd, J J" uniqKey="Headd J">J.J. Headd</name></author><author><name sortKey="Hung, L W" uniqKey="Hung L">L.-W. Hung</name></author><author><name sortKey="Kapral, G J" uniqKey="Kapral G">G.J. Kapral</name></author><author><name sortKey="Grosse Kunstleve, R W" uniqKey="Grosse Kunstleve R">R.W. Grosse-Kunstleve</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mitchell, M S" uniqKey="Mitchell M">M.S. Mitchell</name></author><author><name sortKey="Rao, V B" uniqKey="Rao V">V.B. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dhar, A" uniqKey="Dhar A">A. Dhar</name></author><author><name sortKey="Feiss, M" uniqKey="Feiss M">M. Feiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vologodskii, A" uniqKey="Vologodskii A">A. Vologodskii</name></author><author><name sortKey="Frank Kamenetskii, M D" uniqKey="Frank Kamenetskii M">M.D. Frank-Kamenetskii</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sternberg, N" uniqKey="Sternberg N">N. Sternberg</name></author><author><name sortKey="Coulby, J N" uniqKey="Coulby J">J.N. Coulby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xin, W" uniqKey="Xin W">W. Xin</name></author><author><name sortKey="Cai, Z H" uniqKey="Cai Z">Z.H. Cai</name></author><author><name sortKey="Feiss, M" uniqKey="Feiss M">M. Feiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcnulty, R" uniqKey="Mcnulty R">R. McNulty</name></author><author><name sortKey="Lokareddy, R K" uniqKey="Lokareddy R">R.K. Lokareddy</name></author><author><name sortKey="Roy, A" uniqKey="Roy A">A. Roy</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Lander, G C" uniqKey="Lander G">G.C. Lander</name></author><author><name sortKey="Heck, A J" uniqKey="Heck A">A.J. Heck</name></author><author><name sortKey="Johnson, J E" uniqKey="Johnson J">J.E. Johnson</name></author><author><name sortKey="Cingolani, G" uniqKey="Cingolani G">G. Cingolani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maluf, N K" uniqKey="Maluf N">N.K. Maluf</name></author><author><name sortKey="Gaussier, H" uniqKey="Gaussier H">H. Gaussier</name></author><author><name sortKey="Bogner, E" uniqKey="Bogner E">E. Bogner</name></author><author><name sortKey="Feiss, M" uniqKey="Feiss M">M. Feiss</name></author><author><name sortKey="Catalano, C E" uniqKey="Catalano C">C.E. Catalano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andrews, B T" uniqKey="Andrews B">B.T. Andrews</name></author><author><name sortKey="Catalano, C E" uniqKey="Catalano C">C.E. Catalano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vafabakhsh, R" uniqKey="Vafabakhsh R">R. Vafabakhsh</name></author><author><name sortKey="Kondabagil, K" uniqKey="Kondabagil K">K. Kondabagil</name></author><author><name sortKey="Earnest, T" uniqKey="Earnest T">T. Earnest</name></author><author><name sortKey="Lee, K S" uniqKey="Lee K">K.S. Lee</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Dai, L" uniqKey="Dai L">L. Dai</name></author><author><name sortKey="Dahmen, K A" uniqKey="Dahmen K">K.A. Dahmen</name></author><author><name sortKey="Rao, V B" uniqKey="Rao V">V.B. Rao</name></author><author><name sortKey="Ha, T" uniqKey="Ha T">T. Ha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, P" uniqKey="Zhu P">P. Zhu</name></author><author><name sortKey="Li, G" uniqKey="Li G">G. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cutter, A R" uniqKey="Cutter A">A.R. Cutter</name></author><author><name sortKey="Hayes, J J" uniqKey="Hayes J">J.J. Hayes</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>District de Columbia</li></region></list><tree><country name="États-Unis"><region name="District de Columbia"><name sortKey="Gao, Song" sort="Gao, Song" uniqKey="Gao S" first="Song" last="Gao">Song Gao</name></region><name sortKey="Rao, Venigalla B" sort="Rao, Venigalla B" uniqKey="Rao V" first="Venigalla B." last="Rao">Venigalla B. Rao</name><name sortKey="Zhang, Liang" sort="Zhang, Liang" uniqKey="Zhang L" first="Liang" last="Zhang">Liang Zhang</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Gao, Song" sort="Gao, Song" uniqKey="Gao S" first="Song" last="Gao">Song Gao</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001264 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001264 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4872099
|texte= Exclusion of small terminase mediated DNA threading models for genome packaging in bacteriophage T4
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26984529" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |